3R4B
Crystal Structure of Wild-type HIV-1 Protease in Complex With TMC310911
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B | HIV-1 protease | polymer | 99 | 10815.8 | 2 | UniProt (Q90K99) Pfam (PF00077) UniProt (by SIFTS) (P03369) In PDB | Human immunodeficiency virus 1 | |
| 2 | A | (3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl {(2S,3R)-4-[({2-[(1-cyclopentylpiperidin-4-yl)amino]-1,3-benzothiazol-6-yl}sulfonyl)(2-methylpropyl)amino]-3-hydroxy-1-p henylbutan-2-yl}carbamate | non-polymer | 756.0 | 1 | Chemie (74T) | |||
| 3 | A | PHOSPHATE ION | non-polymer | 95.0 | 1 | Chemie (PO4) | |||
| 4 | water | water | 18.0 | 96 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 99 (UniProt: Q90K99)
| PDB | External Database | Details |
|---|---|---|
| Lys 7 | Gln 7 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 21631.6 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 851.0 | |
| All* | Total formula weight | 22482.5 |
