3QYW

Crystal structure of ERK2 in complex with an inhibitor

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Mitogen-activated protein kinase 1	polymer	364	42235.5	1	UniProt (P63086) Pfam (PF00069) In PDB	Rattus norvegicus (brown rat rat rats)	MAP kinase 1, MAPK 1, ERT1, Extracellular signal-regulated kinase 2, ERK-2, MAP kinase isoform p42, p42-MAPK, Mitogen-activated protein kinase 2, MAP kinase 2, MAPK 2
2	A	6-(3-bromophenyl)-7H-purin-2-amine	non-polymer		290.1	1	Chemie (6PB)
3	A	DIMETHYL SULFOXIDE	non-polymer		78.1	10	Chemie (DMS)
4	A	SULFATE ION	non-polymer		96.1	1	Chemie (SO4)
5		water	water		18.0	450	Chemie (HOH)

Sequence modifications

A: 1 - 358 (UniProt: P63086)

PDB	External Database	Details
His -5	-	EXPRESSION TAG
His -4	-	EXPRESSION TAG
His -3	-	EXPRESSION TAG
His -2	-	EXPRESSION TAG
His -1	-	EXPRESSION TAG
His 0	-	EXPRESSION TAG

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	42235.5
Non-Polymers*	Number of molecules	12
	Total formula weight	1167.5
All*	Total formula weight	43403.1

*Water molecules are not included.