3QYL
Sensitivity of receptor internal motions to ligand binding affinity and kinetic off-rate
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Dihydrofolate reductase | polymer | 159 | 18020.3 | 1 | UniProt (P0ABQ4) Pfam (PF00186) In PDB | Escherichia coli K-12 | |
| 2 | A | (7S)-7-methyl-5,6,7,8-tetrahydroquinazoline-2,4-diamine | non-polymer | 178.2 | 1 | Chemie (7ME) | |||
| 3 | A | NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | non-polymer | 745.4 | 1 | Chemie (NDP) | |||
| 4 | A | CALCIUM ION | non-polymer | 40.1 | 2 | Chemie (CA) | |||
| 5 | A | CHLORIDE ION | non-polymer | 35.5 | 1 | Chemie (CL) | |||
| 6 | water | water | 18.0 | 198 | Chemie (HOH) |
Sequence modifications
A: 1 - 159 (UniProt: P0ABQ4)
| PDB | External Database | Details |
|---|---|---|
| Asp 37 | Asn 37 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 18020.3 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 1039.3 | |
| All* | Total formula weight | 19059.6 |
