3QXM

Crystal Structure of Human GluK2 Ligand-Binding Core in Complex with Novel Marine-Derived Toxins, Neodysiherbaine A

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Glutamate receptor ionotropic, kainate 2	polymer	258	29286.5	2	UniProt (Q13002) Pfam (PF10613) Pfam (PF00060)	Homo sapiens (Human)	GluK2,Excitatory amino acid receptor 4,EAA4,Glutamate receptor 6,GluR6
2	C, D (A, B)	(2R,3aR,6R,7R,7aR)-2-[(2S)-2-amino-2-carboxyethyl]-6,7-dihydroxyhexahydro-2H-furo[3,2-b]pyran-2-carboxylic acid	non-polymer		291.3	2	Chemie (NDZ)
3	E, F (A, B)	water	water		18.0	474	Chemie (HOH)

Sequence modifications

A, B: 398 - 513 (UniProt: Q13002)
A, B: 636 - 775 (UniProt: Q13002)

PDB	External Database	Details
Gly 600	-	linker
Thr 601	-	linker

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	58573.1
Non-Polymers*	Number of molecules	2
	Total formula weight	582.5
All*	Total formula weight	59155.6

*Water molecules are not included.