3QS7
Crystal structure of a human Flt3 ligand-receptor ternary complex
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B, C, D | SL cytokine | polymer | 138 | 15873.2 | 4 | UniProt (P49771) Pfam (PF02947) In PDB | Homo sapiens (human) | Flt3 ligand, Fms-related tyrosine kinase 3 ligand, Flt3L |
2 | E, F, G, H | FL cytokine receptor | polymer | 423 | 48099.2 | 4 | UniProt (P36888) Pfam (PF00047) In PDB | Homo sapiens (human) | Tyrosine-protein kinase receptor FLT3, Fms-like tyrosine kinase 3, FLT-3, Stem cell tyrosine kinase 1, STK-1 |
3 | E, F, G, H | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 7 | Chemie (NAG) |
Sequence modifications
A, B, C, D: 1 - 134 (UniProt: P49771)
E, F, G, H: 27 - 436 (UniProt: P36888)
PDB | External Database | Details |
---|---|---|
Gly -3 | - | expression tag |
Ser -2 | - | expression tag |
His -1 | - | expression tag |
Met 0 | - | expression tag |
PDB | External Database | Details |
---|---|---|
Glu 24 | - | expression tag |
Thr 25 | - | expression tag |
Gly 26 | - | expression tag |
Ser 437 | - | expression tag |
Gly 438 | - | expression tag |
Thr 439 | - | expression tag |
Lys 440 | - | expression tag |
His 441 | - | expression tag |
His 442 | - | expression tag |
His 443 | - | expression tag |
His 444 | - | expression tag |
His 445 | - | expression tag |
His 446 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 8 |
Total formula weight | 255889.6 | |
Non-Polymers* | Number of molecules | 7 |
Total formula weight | 1548.5 | |
All* | Total formula weight | 257438.1 |