3QS7

Crystal structure of a human Flt3 ligand-receptor ternary complex

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D (A, B, C, D)	SL cytokine	polymer	138	15873.2	4	UniProt (P49771) Pfam (PF02947)	Homo sapiens (human)	Flt3 ligand, Fms-related tyrosine kinase 3 ligand, Flt3L
2	E, F, G, H (E, F, G, H)	FL cytokine receptor	polymer	423	48099.2	4	UniProt (P36888) Pfam (PF00047)	Homo sapiens (human)	Tyrosine-protein kinase receptor FLT3, Fms-like tyrosine kinase 3, FLT-3, Stem cell tyrosine kinase 1, STK-1
3	I, J, K, L, M... (E, F, G, H)	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	7	Chemie (NAG)

Sequence modifications

A, B, C, D: 1 - 134 (UniProt: P49771)

PDB	External Database	Details
Gly -3	-	expression tag
Ser -2	-	expression tag
His -1	-	expression tag
Met 0	-	expression tag

E, F, G, H: 27 - 436 (UniProt: P36888)

PDB	External Database	Details
Glu 24	-	expression tag
Thr 25	-	expression tag
Gly 26	-	expression tag
Ser 437	-	expression tag
Gly 438	-	expression tag
Thr 439	-	expression tag
Lys 440	-	expression tag
His 441	-	expression tag
His 442	-	expression tag
His 443	-	expression tag
His 444	-	expression tag
His 445	-	expression tag
His 446	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	8
	Total formula weight	255889.6
Non-Polymers*	Number of molecules	7
	Total formula weight	1548.5
All*	Total formula weight	257438.1

*Water molecules are not included.