3QRK
The crystal structure of human abl1 kinase domain in complex with DP-987
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Tyrosine-protein kinase ABL1 | polymer | 277 | 32110.7 | 1 | UniProt (P00519) Pfam (PF07714) | Homo sapiens (human) | Abelson murine leukemia viral oncogene homolog 1, Proto-oncogene c-Abl, p150 |
| 2 | B (A) | (3S)-6-(3-tert-butyl-5-{[(2,3-dichlorophenyl)carbamoyl]amino}-1H-pyrazol-1-yl)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid | non-polymer | 502.4 | 1 | Chemie (9DP) | |||
| 3 | C (A) | water | water | 18.0 | 138 | Chemie (HOH) |
Sequence modifications
A: 229 - 499 (UniProt: P00519)
| PDB | External Database | Details |
|---|---|---|
| Thr 223 | - | expression tag |
| Ser 224 | - | expression tag |
| Met 225 | - | expression tag |
| Asp 226 | - | expression tag |
| Pro 227 | - | expression tag |
| Ser 228 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 32110.7 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 502.4 | |
| All* | Total formula weight | 32613.1 |
