3QNF
Crystal structure of the open state of human endoplasmic reticulum aminopeptidase 1 ERAP1
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C (A, B, C) | Endoplasmic reticulum aminopeptidase 1 | polymer | 954 | 109071.5 | 3 | UniProt (Q9NZ08) Pfam (PF17900) Pfam (PF01433) Pfam (PF11838) | Homo sapiens (human) | ARTS-1, Adipocyte-derived leucine aminopeptidase, A-LAP, Aminopeptidase PILS, Puromycin-insensitive leucyl-specific aminopeptidase, PILS-AP, Type 1 tumor necrosis factor receptor shedding aminopeptidase regulator |
| 2 | D (D) | alpha-D-mannopyranose-(1-6)-alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 748.7 | 1 | In PDB GlyTouCan (G04854NQ) | |||
| 3 | E, F, I (A, B, C) | ZINC ION | non-polymer | 65.4 | 3 | Chemie (ZN) | |||
| 4 | G, H, J, K (B, C) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 4 | Chemie (NAG) | |||
| 5 | L, M, N (A, B, C) | water | water | 18.0 | 39 | Chemie (HOH) |
Sequence modifications
A, B, C: 1 - 941 (UniProt: Q9NZ08)
| PDB | External Database | Details |
|---|---|---|
| Leu -5 | - | expression tag |
| Arg -4 | - | expression tag |
| Arg -3 | - | expression tag |
| Arg -2 | - | expression tag |
| Tyr -1 | - | expression tag |
| Thr 0 | - | expression tag |
| Ala 942 | - | expression tag |
| Glu 943 | - | expression tag |
| Asn 944 | - | expression tag |
| Leu 945 | - | expression tag |
| Tyr 946 | - | expression tag |
| Phe 947 | - | expression tag |
| Gln 948 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 327214.5 | |
| Branched | Number of molecules | 1 |
| Total formula weight | 748.7 | |
| Non-Polymers* | Number of molecules | 7 |
| Total formula weight | 1081.1 | |
| All* | Total formula weight | 329044.2 |
