3QMG

Structural Basis of Selective Binding of Non-Methylated CpG islands by the CXXC Domain of CFP1

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	CpG-binding protein	polymer	79	9528.0	1	UniProt (Q9P0U4) Pfam (PF02008) In PDB	Homo sapiens (human)	CXXC-type zinc finger protein 1, PHD finger and CXXC domain-containing protein 1
2	B	5'-D(*GP*CP*CP*AP*AP*CP*GP*GP*TP*GP*GP*C)-3'	polymer	12	3688.4	1
3	C	5'-D(*GP*CP*CP*AP*CP*CP*GP*TP*TP*GP*GP*C)-3'	polymer	12	3639.4	1
4	A	ZINC ION	non-polymer		65.4	2	Chemie (ZN)
5	A	DI(HYDROXYETHYL)ETHER	non-polymer		106.1	1	Chemie (PEG)
6		water	water		18.0	10	Chemie (HOH)

Sequence modifications

A: 161 - 222 (UniProt: Q9P0U4)

PDB	External Database	Details
Met 144	-	expression tag
His 145	-	expression tag
His 146	-	expression tag
His 147	-	expression tag
His 148	-	expression tag
His 149	-	expression tag
His 150	-	expression tag
Ser 151	-	expression tag
Ser 152	-	expression tag
Arg 153	-	expression tag
Glu 154	-	expression tag
Asn 155	-	expression tag
Leu 156	-	expression tag
Tyr 157	-	expression tag
Phe 158	-	expression tag
Gln 159	-	expression tag
Gly 160	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	3
	Total formula weight	16855.7
Non-Polymers*	Number of molecules	3
	Total formula weight	236.9
All*	Total formula weight	17092.7

*Water molecules are not included.