3QMG
Structural Basis of Selective Binding of Non-Methylated CpG islands by the CXXC Domain of CFP1
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | CpG-binding protein | polymer | 79 | 9528.0 | 1 | UniProt (Q9P0U4) Pfam (PF02008) | Homo sapiens (human) | CXXC-type zinc finger protein 1, PHD finger and CXXC domain-containing protein 1 |
| 2 | B (B) | 5'-D(*GP*CP*CP*AP*AP*CP*GP*GP*TP*GP*GP*C)-3' | polymer | 12 | 3688.4 | 1 | |||
| 3 | C (C) | 5'-D(*GP*CP*CP*AP*CP*CP*GP*TP*TP*GP*GP*C)-3' | polymer | 12 | 3639.4 | 1 | |||
| 4 | D, E (A) | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) | |||
| 5 | F (A) | DI(HYDROXYETHYL)ETHER | non-polymer | 106.1 | 1 | Chemie (PEG) | |||
| 6 | G, H (A, B) | water | water | 18.0 | 10 | Chemie (HOH) |
Sequence modifications
A: 161 - 222 (UniProt: Q9P0U4)
| PDB | External Database | Details |
|---|---|---|
| Met 144 | - | expression tag |
| His 145 | - | expression tag |
| His 146 | - | expression tag |
| His 147 | - | expression tag |
| His 148 | - | expression tag |
| His 149 | - | expression tag |
| His 150 | - | expression tag |
| Ser 151 | - | expression tag |
| Ser 152 | - | expression tag |
| Arg 153 | - | expression tag |
| Glu 154 | - | expression tag |
| Asn 155 | - | expression tag |
| Leu 156 | - | expression tag |
| Tyr 157 | - | expression tag |
| Phe 158 | - | expression tag |
| Gln 159 | - | expression tag |
| Gly 160 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 16855.7 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 236.9 | |
| All* | Total formula weight | 17092.7 |
