3QMC

Structural Basis of Selective Binding of Nonmethylated CpG Islands by the CXXC Domain of CFP1

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	CpG-binding protein	polymer	79	9528.0	1	UniProt (Q9P0U4) Pfam (PF02008)	Homo sapiens (human)	CXXC-type zinc finger protein 1, PHD finger and CXXC domain-containing protein 1
2	B (B)	5'-D(*GP*CP*CP*AP*CP*CP*GP*CP*TP*GP*GP*C)-3'	polymer	12	3624.4	1
3	C (C)	5'-D(*GP*CP*CP*AP*GP*CP*GP*GP*TP*GP*GP*C)-3'	polymer	12	3704.4	1
4	D, E (A)	ZINC ION	non-polymer		65.4	2	Chemie (ZN)
5	F, G, H (A, B, C)	water	water		18.0	22	Chemie (HOH)

Sequence modifications

A: 165 - 226 (UniProt: Q9P0U4)

PDB	External Database	Details
Met 148	-	expression tag
His 149	-	expression tag
His 150	-	expression tag
His 151	-	expression tag
His 152	-	expression tag
His 153	-	expression tag
His 154	-	expression tag
Ser 155	-	expression tag
Ser 156	-	expression tag
Arg 157	-	expression tag
Glu 158	-	expression tag
Asn 159	-	expression tag
Leu 160	-	expression tag
Tyr 161	-	expression tag
Phe 162	-	expression tag
Gln 163	-	expression tag
Gly 164	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	3
	Total formula weight	16856.7
Non-Polymers*	Number of molecules	2
	Total formula weight	130.8
All*	Total formula weight	16987.5

*Water molecules are not included.