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3QJZ

Crystal structure of PI3K-gamma in complex with benzothiazole 1

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A
(A)
Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoformpolymer960109824.11UniProt (P48736)
Pfam (PF00794)
Pfam (PF00792)
Pfam (PF00613)
Pfam (PF00454)
Homo sapiens (human)PI3-kinase subunit gamma, PI3K-gamma, PtdIns-3-kinase subunit gamma, Phosphatidylinositol-4,5-bisphosphate 3-kinase 110 kDa catalytic subunit gamma, PtdIns-3-kinase subunit p110-gamma, p120-PI3K
2B
(A)
N-{6-[2-(methylsulfanyl)pyrimidin-4-yl]-1,3-benzothiazol-2-yl}acetamidenon-polymer316.41Chemie (QJZ)
3C
(A)
SULFATE IONnon-polymer96.11Chemie (SO4)
4D
(A)
waterwater18.03Chemie (HOH)
Sequence modifications
A: 144 - 1102 (UniProt: P48736)
PDBExternal DatabaseDetails
Gly 143-expression tag
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains1
Total formula weight109824.1
Non-Polymers*Number of molecules2
Total formula weight412.5
All*Total formula weight110236.5
*Water molecules are not included.

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PDB entries from 2025-07-16

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