3QIC

The structure of human glucokinase E339K mutation

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Glucokinase	polymer	470	53076.2	1	UniProt (P35557) Pfam (PF00349) Pfam (PF03727) In PDB	Homo sapiens (human)	Hexokinase type IV, HK IV, Hexokinase-4, HK4, Hexokinase-D
2	A	alpha-D-glucopyranose	non-polymer		180.2	1	Chemie (GLC)
3	A	GLYCEROL	non-polymer		92.1	6	Chemie (GOL)
4		water	water		18.0	51	Chemie (HOH)

Sequence modifications

A: 12 - 465 (UniProt: P35557)

PDB	External Database	Details
Met -4	-	expression tag
Gly -3	-	expression tag
His -2	-	expression tag
His -1	-	expression tag
His 0	-	expression tag
His 1	-	expression tag
His 2	-	expression tag
His 3	-	expression tag
Glu 4	-	expression tag
Asn 5	-	expression tag
Leu 6	-	expression tag
Tyr 7	-	expression tag
Phe 8	-	expression tag
Gln 9	-	expression tag
Gly 10	-	expression tag
Met 11	-	expression tag
Lys 339	Glu 339	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	53076.2
Non-Polymers*	Number of molecules	7
	Total formula weight	732.7
All*	Total formula weight	53809.0

*Water molecules are not included.