3QFC
Crystal Structure of Human NADPH-Cytochrome P450 (V492E mutant)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | NADPH--cytochrome P450 reductase | polymer | 618 | 70160.0 | 2 | UniProt (P16435) Pfam (PF00258) Pfam (PF00667) Pfam (PF00175) | Homo sapiens (human) | CPR, P450R |
| 2 | C, G (A, B) | FLAVIN-ADENINE DINUCLEOTIDE | non-polymer | 785.5 | 2 | Chemie (FAD) | |||
| 3 | D, H (A, B) | FLAVIN MONONUCLEOTIDE | non-polymer | 456.3 | 2 | Chemie (FMN) PubChem (710) PubChem (8965) PubChem (23585816) PubChem (643976) PubChem (51435500) PubChem (51435503) PubChem (5702760) PubChem (7048779) PubChem (7048781) PubChem (15559251) | |||
| 4 | E, I (A, B) | NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | non-polymer | 743.4 | 2 | Chemie (NAP) PubChem (5885) PubChem (46936685) PubChem (71717786) PubChem (4412) PubChem (90473931) PubChem (91972139) PubChem (145946263) PubChem (153311489) PubChem (174001641) PubChem (165382010) | |||
| 5 | F (A) | CALCIUM ION | non-polymer | 40.1 | 1 | Chemie (CA) PubChem (271) | |||
| 6 | J, K (A, B) | water | water | 18.0 | 720 | Chemie (HOH) |
Sequence modifications
A, B: 67 - 680 (UniProt: P16435)
| PDB | External Database | Details |
|---|---|---|
| Gly 63 | - | expression tag |
| Ser 64 | - | expression tag |
| His 65 | - | expression tag |
| Met 66 | - | expression tag |
| Leu 228 | Pro 225 | SEE REMARK 999 |
| Glu 492 | Val 489 | engineered mutation |
| Val 503 | Ala 500 | SEE REMARK 999 |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 140319.9 | |
| Non-Polymers* | Number of molecules | 7 |
| Total formula weight | 4010.7 | |
| All* | Total formula weight | 144330.6 |
