3QFB
Crystal structure of the human thioredoxin reductase-thioredoxin complex
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Thioredoxin reductase 1, cytoplasmic | polymer | 519 | 56925.8 | 2 | UniProt (Q16881) Pfam (PF07992) Pfam (PF02852) | Homo sapiens (human) | TR, Gene associated with retinoic and interferon-induced mortality 12 protein, GRIM-12, Gene associated with retinoic and IFN-induced mortality 12 protein, KM-102-derived reductase-like factor, Thioredoxin reductase TR1 |
| 2 | C, D (C, D) | Thioredoxin | polymer | 116 | 12992.7 | 2 | UniProt (P10599) Pfam (PF00085) | Homo sapiens (human) | Trx, ATL-derived factor, ADF, Surface-associated sulphydryl protein, SASP |
| 3 | E, J (A, B) | FLAVIN-ADENINE DINUCLEOTIDE | non-polymer | 785.5 | 2 | Chemie (FAD) | |||
| 4 | F, G, H, I, K... (A, B) | GLYCEROL | non-polymer | 92.1 | 6 | Chemie (GOL) | |||
| 5 | M, N, O, P (A, B, C, D) | water | water | 18.0 | 241 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 499 (UniProt: Q16881)
C, D: 2 - 105 (UniProt: P10599)
| PDB | External Database | Details |
|---|---|---|
| Met -19 | - | expression tag |
| Gly -18 | - | expression tag |
| Ser -17 | - | expression tag |
| Ser -16 | - | expression tag |
| His -15 | - | expression tag |
| His -14 | - | expression tag |
| His -13 | - | expression tag |
| His -12 | - | expression tag |
| His -11 | - | expression tag |
| His -10 | - | expression tag |
| Ser -9 | - | expression tag |
| Ser -8 | - | expression tag |
| Gly -7 | - | expression tag |
| Leu -6 | - | expression tag |
| Val -5 | - | expression tag |
| Pro -4 | - | expression tag |
| Arg -3 | - | expression tag |
| Gly -2 | - | expression tag |
| Ser -1 | - | expression tag |
| His 0 | - | expression tag |
| Ser 497 | Cys 497 | engineered mutation |
| Cys 498 | U 498 | SEE REMARK 999 |
| PDB | External Database | Details |
|---|---|---|
| Met -10 | - | expression tag |
| Arg -9 | - | expression tag |
| Gly -8 | - | expression tag |
| Ser -7 | - | expression tag |
| His -6 | - | expression tag |
| His -5 | - | expression tag |
| His -4 | - | expression tag |
| His -3 | - | expression tag |
| His -2 | - | expression tag |
| His -1 | - | expression tag |
| Gly 0 | - | expression tag |
| Ser 1 | - | expression tag |
| Ser 35 | Cys 35 | engineered mutation |
| Ser 73 | Cys 73 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 139837.0 | |
| Non-Polymers* | Number of molecules | 8 |
| Total formula weight | 2123.7 | |
| All* | Total formula weight | 141960.6 |
