3QEL

Crystal structure of amino terminal domains of the NMDA receptor subunit GluN1 and GluN2B in complex with ifenprodil

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, C	NMDA glutamate receptor subunit	polymer	383	42932.1	2	UniProt (Q91977) Pfam (PF01094) UniProt (by SIFTS) (A0A1L8F5J9) In PDB	Xenopus laevis (African clawed frog)
2	B, D	Glutamate [NMDA] receptor subunit epsilon-2	polymer	364	41367.9	2	UniProt (Q00960) Pfam (PF01094) In PDB	Rattus norvegicus (rat)	N-methyl D-aspartate receptor subtype 2B, NMDAR2B, NR2B
3	E	alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-3)]2-acetamido-2-deoxy-beta-D-glucopyranose	branched		1057.0	1	In PDB GlyTouCan (G43648DB)
4	A, C	SODIUM ION	non-polymer		23.0	2	Chemie (NA)
5	A, B, C, D	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	6	Chemie (NAG)
6	B, D	4-[(1R,2S)-2-(4-benzylpiperidin-1-yl)-1-hydroxypropyl]phenol	non-polymer		325.4	2	Chemie (QEL)
7		water	water		18.0	137	Chemie (HOH)

Sequence modifications

A, C: 23 - 405 (UniProt: Q91977)

PDB	External Database	Details
Gln 61	Asn 61	engineered mutation
Gln 371	Asn 371	engineered mutation

B, D: 31 - 394 (UniProt: Q00960)

PDB	External Database	Details
Asp 348	Asn 348	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	168599.9
Branched	Number of molecules	1
	Total formula weight	1057.0
Non-Polymers*	Number of molecules	10
	Total formula weight	2024.1
All*	Total formula weight	171681.0

*Water molecules are not included.