3QEL
Crystal structure of amino terminal domains of the NMDA receptor subunit GluN1 and GluN2B in complex with ifenprodil
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C (A, C) | NMDA glutamate receptor subunit | polymer | 383 | 42932.1 | 2 | UniProt (Q91977) Pfam (PF01094) UniProt (by SIFTS) (A0A1L8F5J9) | Xenopus laevis (African clawed frog) | |
| 2 | B, D (B, D) | Glutamate [NMDA] receptor subunit epsilon-2 | polymer | 364 | 41367.9 | 2 | UniProt (Q00960) Pfam (PF01094) | Rattus norvegicus (rat) | N-methyl D-aspartate receptor subtype 2B, NMDAR2B, NR2B |
| 3 | E (E) | alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-3)]2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 1057.0 | 1 | In PDB GlyTouCan (G43648DB) | |||
| 4 | F, K (A, C) | SODIUM ION | non-polymer | 23.0 | 2 | Chemie (NA) | |||
| 5 | G, H, I, L, M... (A, B, C, D) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 6 | Chemie (NAG) | |||
| 6 | J, O (B, D) | 4-[(1R,2S)-2-(4-benzylpiperidin-1-yl)-1-hydroxypropyl]phenol | non-polymer | 325.4 | 2 | Chemie (QEL) | |||
| 7 | P, Q, R, S (A, B, C, D) | water | water | 18.0 | 137 | Chemie (HOH) |
Sequence modifications
A, C: 23 - 405 (UniProt: Q91977)
B, D: 31 - 394 (UniProt: Q00960)
| PDB | External Database | Details |
|---|---|---|
| Gln 61 | Asn 61 | engineered mutation |
| Gln 371 | Asn 371 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Asp 348 | Asn 348 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 168599.9 | |
| Branched | Number of molecules | 1 |
| Total formula weight | 1057.0 | |
| Non-Polymers* | Number of molecules | 10 |
| Total formula weight | 2024.1 | |
| All* | Total formula weight | 171681.0 |
