3QC4
PDK1 in complex with DFG-OUT inhibitor xxx
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | 3-phosphoinositide-dependent protein kinase 1 | polymer | 314 | 35722.9 | 2 | UniProt (O15530) Pfam (PF00069) | Homo sapiens (human) | hPDK1 |
| 2 | C, D (A, B) | 1-(3,4-difluorobenzyl)-2-oxo-N-{(1R)-2-[(2-oxo-2,3-dihydro-1H-benzimidazol-5-yl)oxy]-1-phenylethyl}-1,2-dihydropyridine-3-carboxamide | non-polymer | 516.5 | 2 | Chemie (MP7) | |||
| 3 | E, F (A, B) | water | water | 18.0 | 425 | Chemie (HOH) |
Sequence modifications
A, B: 51 - 359 (UniProt: O15530)
| PDB | External Database | Details |
|---|---|---|
| Gly -5 | - | expression tag |
| Pro -4 | - | expression tag |
| Leu -3 | - | expression tag |
| Gly -2 | - | expression tag |
| Ser -1 | - | expression tag |
| Ala 303 | Glu 303 | engineered mutation |
| Ala 304 | Lys 304 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 71445.8 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 1033.0 | |
| All* | Total formula weight | 72478.8 |
