3QBJ
Crystal structure of dipeptidyl peptidase IV in complex with inhibitor
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | Dipeptidyl peptidase 4 | polymer | 748 | 86562.9 | 2 | UniProt (P27487) Pfam (PF00930) Pfam (PF00326) In PDB | Homo sapiens (human) | ADABP, Adenosine deaminase complexing protein 2, ADCP-2, Dipeptidyl peptidase IV, DPP IV, T-cell activation antigen CD26, TP103, Dipeptidyl peptidase IV soluble form |
2 | C, E | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 2 | In PDB GlyTouCan (G42666HT) | |||
3 | D | alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 748.7 | 1 | In PDB GlyTouCan (G81315DD) | |||
4 | A, B | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 3 | Chemie (NAG) | |||
5 | A, B | 1-[(3S,4S)-4-amino-1-(6-phenylpyrimidin-4-yl)pyrrolidin-3-yl]piperidin-2-one | non-polymer | 337.4 | 2 | Chemie (NXZ) | |||
6 | water | water | 18.0 | 71 | Chemie (HOH) |
Sequence modifications
A, B: 31 - 766 (UniProt: P27487)
PDB | External Database | Details |
---|---|---|
Ala 150 | Asn 150 | engineered mutation |
Ala 520 | Asn 520 | engineered mutation |
Leu 767 | - | expression tag |
Val 768 | - | expression tag |
Pro 769 | - | expression tag |
Arg 770 | - | expression tag |
Gly 771 | - | expression tag |
Ser 772 | - | expression tag |
His 773 | - | expression tag |
His 774 | - | expression tag |
His 775 | - | expression tag |
His 776 | - | expression tag |
His 777 | - | expression tag |
His 778 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 173125.8 | |
Branched | Number of molecules | 3 |
Total formula weight | 1597.5 | |
Non-Polymers* | Number of molecules | 5 |
Total formula weight | 1338.5 | |
All* | Total formula weight | 176061.7 |