3QAQ
Crystal structure of PI3K-gamma in complex with triazine-benzimidazole 1
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | polymer | 960 | 109824.1 | 1 | UniProt (P48736) Pfam (PF00794) Pfam (PF00792) Pfam (PF00613) Pfam (PF00454) In PDB | Homo sapiens (human) | PI3-kinase subunit gamma, PI3K-gamma, PtdIns-3-kinase subunit gamma, Phosphatidylinositol-4,5-bisphosphate 3-kinase 110 kDa catalytic subunit gamma, PtdIns-3-kinase subunit p110-gamma, p120-PI3K |
| 2 | A | SULFATE ION | non-polymer | 96.1 | 3 | Chemie (SO4) | |||
| 3 | A | [(4-{2-[(3-hydroxyphenyl)amino]-1H-benzimidazol-1-yl}-1,3,5-triazin-2-yl)amino]acetonitrile | non-polymer | 358.4 | 1 | Chemie (QAQ) | |||
| 4 | water | water | 18.0 | 13 | Chemie (HOH) |
Sequence modifications
A: 144 - 1102 (UniProt: P48736)
| PDB | External Database | Details |
|---|---|---|
| Gly 143 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 109824.1 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 646.5 | |
| All* | Total formula weight | 110470.6 |
