3Q93

Crystal Structure of Human 8-oxo-dGTPase (MTH1)

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	7,8-dihydro-8-oxoguanine triphosphatase	polymer	176	20142.8	2	UniProt (P36639) Pfam (PF00293) In PDB	Homo sapiens (human)	8-oxo-dGTPase, Nucleoside diphosphate-linked moiety X motif 1, Nudix motif 1
2	A, B	SULFATE ION	non-polymer		96.1	5	Chemie (SO4)
3	A	IMIDAZOLE	non-polymer		69.1	1	Chemie (IMD)
4	A	GLYCEROL	non-polymer		92.1	2	Chemie (GOL)
5		water	water		18.0	215	Chemie (HOH)

Sequence modifications

A, B: 1 - 156 (UniProt: P36639)

PDB	External Database	Details
Met -19	-	expression tag
Gly -18	-	expression tag
Ser -17	-	expression tag
Ser -16	-	expression tag
His -15	-	expression tag
His -14	-	expression tag
His -13	-	expression tag
His -12	-	expression tag
His -11	-	expression tag
His -10	-	expression tag
Ser -9	-	expression tag
Ser -8	-	expression tag
Gly -7	-	expression tag
Leu -6	-	expression tag
Val -5	-	expression tag
Pro -4	-	expression tag
Arg -3	-	expression tag
Gly -2	-	expression tag
Ser -1	-	expression tag
His 0	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	40285.7
Non-Polymers*	Number of molecules	8
	Total formula weight	733.6
All*	Total formula weight	41019.3

*Water molecules are not included.