3Q4C
Crystal Structure of Wild Type BRAF kinase domain in complex with organometallic inhibitor CNS292
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | Serine/threonine-protein kinase B-raf | polymer | 307 | 35217.6 | 2 | UniProt (P15056) Pfam (PF07714) In PDB | Homo sapiens (human) | Proto-oncogene B-Raf, p94, v-Raf murine sarcoma viral oncogene homolog B1 |
2 | A | [(1,2,3,4,5,6-eta)-(1S,2R,3R,4R,5S,6S)-1-carboxycyclohexane-1,2,3,4,5,6-hexayl](chloro)(3-methyl-5,7-dioxo-6,7-dihydro-5H-pyrido[2,3-a]pyrrolo[3,4-c]carbazol-12-ide-kappa~2~N~1~,N~12~)ruthenium(1+) | non-polymer | 558.9 | 1 | Chemie (RSW) |
Sequence modifications
A, B: 431 - 725 (UniProt: P15056)
PDB | External Database | Details |
---|---|---|
Met 419 | - | expression tag |
Asp 420 | - | expression tag |
Arg 421 | - | expression tag |
Gly 422 | - | expression tag |
Ser 423 | - | expression tag |
His 424 | - | expression tag |
His 425 | - | expression tag |
His 426 | - | expression tag |
His 427 | - | expression tag |
His 428 | - | expression tag |
His 429 | - | expression tag |
Gly 430 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 70435.3 | |
Non-Polymers* | Number of molecules | 1 |
Total formula weight | 558.9 | |
All* | Total formula weight | 70994.2 |