3Q44
X-ray crystal structure of PfA-M1 bound to Bestatin derivative 16
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | M1 family aminopeptidase | polymer | 891 | 103873.9 | 1 | UniProt (O96935) Pfam (PF17900) Pfam (PF01433) Pfam (PF11940) Pfam (PF17432) In PDB | Plasmodium falciparum FcB1/Columbia | Pfa-M1 |
| 2 | A | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) | |||
| 3 | A | N-{(2S,3R)-3-amino-4-[4-(benzyloxy)phenyl]-2-hydroxybutanoyl}-L-leucine | non-polymer | 414.5 | 1 | Chemie (D50) | |||
| 4 | A | GLYCEROL | non-polymer | 92.1 | 2 | Chemie (GOL) | |||
| 5 | A | MAGNESIUM ION | non-polymer | 24.3 | 1 | Chemie (MG) | |||
| 6 | water | water | 18.0 | 1020 | Chemie (HOH) |
Sequence modifications
A: 195 - 1085 (UniProt: O96935)
| PDB | External Database | Details |
|---|---|---|
| Gln 213 | Asn 213 | engineered mutation |
| Gln 223 | Asn 223 | engineered mutation |
| Pro 378 | His 378 | engineered mutation |
| Gln 501 | Asn 501 | engineered mutation |
| Gln 745 | Asn 745 | engineered mutation |
| Gln 795 | Asn 795 | engineered mutation |
| Gln 1069 | Asn 1069 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 103873.9 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 688.4 | |
| All* | Total formula weight | 104562.3 |
