3PP1

Crystal Structure of the Human Mitogen-activated protein kinase kinase 1 (MEK 1) in complex with ligand and MgATP

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Dual specificity mitogen-activated protein kinase kinase 1	polymer	328	36640.2	1	UniProt (Q02750) Pfam (PF00069) In PDB	Homo sapiens (human)	MAP kinase kinase 1, MAPKK 1, ERK activator kinase 1, MAPK/ERK kinase 1, MEK 1
2	A	ADENOSINE-5'-TRIPHOSPHATE	non-polymer		507.2	1	Chemie (ATP)
3	A	MAGNESIUM ION	non-polymer		24.3	1	Chemie (MG)
4	A	3-[(2R)-2,3-dihydroxypropyl]-6-fluoro-5-[(2-fluoro-4-iodophenyl)amino]-8-methylpyrido[2,3-d]pyrimidine-4,7(3H,8H)-dione	non-polymer		504.2	1	Chemie (IZG)
5	A	ACETATE ION	non-polymer		59.0	1	Chemie (ACT)
6		water	water		18.0	68	Chemie (HOH)

Sequence modifications

A: 62 - 382 (UniProt: Q02750)

PDB	External Database	Details
Met 61	-	initiating methionine
His 383	-	expression tag
His 384	-	expression tag
His 385	-	expression tag
His 386	-	expression tag
His 387	-	expression tag
His 388	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	36640.2
Non-Polymers*	Number of molecules	4
	Total formula weight	1094.8
All*	Total formula weight	37735.0

*Water molecules are not included.