3PJ8
Structure of CDK2 in complex with a Pyrazolo[4,3-d]pyrimidine Bioisostere of Roscovitine.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Cell division protein kinase 2 | polymer | 299 | 34033.5 | 1 | UniProt (P24941) Pfam (PF00069) | Homo sapiens (human) | p33 protein kinase |
| 2 | B (A) | (2R)-2-{[7-(benzylamino)-3-(propan-2-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]amino}butan-1-ol | non-polymer | 354.4 | 1 | Chemie (404) | |||
| 3 | C (A) | water | water | 18.0 | 146 | Chemie (HOH) |
Sequence modifications
A: 1 - 298 (UniProt: P24941)
| PDB | External Database | Details |
|---|---|---|
| Gly 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 34033.5 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 354.4 | |
| All* | Total formula weight | 34388.0 |
