3PJ3
Crystal structure of BTK kinase domain complexed with 2-Methyl-5-[(E)-(3-phenyl-acryloyl)amino]-N-(2-phenyl-3H-imidazo[4,5-b]pyridin-6-yl)-benzamide
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Tyrosine-protein kinase BTK | polymer | 274 | 31827.5 | 1 | UniProt (Q06187) Pfam (PF07714) In PDB | Homo sapiens (human) | Agammaglobulinaemia tyrosine kinase, ATK, B-cell progenitor kinase, BPK, Bruton tyrosine kinase |
| 2 | A | 2-methyl-N-(2-phenyl-3H-imidazo[4,5-b]pyridin-6-yl)-5-{[(2E)-3-phenylprop-2-enoyl]amino}benzamide | non-polymer | 473.5 | 1 | Chemie (04L) | |||
| 3 | water | water | 18.0 | 96 | Chemie (HOH) |
Sequence modifications
A: 387 - 659 (UniProt: Q06187)
| PDB | External Database | Details |
|---|---|---|
| Gly 386 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 31827.5 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 473.5 | |
| All* | Total formula weight | 32301.0 |
