3PIZ
Crystal structure of BTK kinase domain complexed with (5-Amino-1-o-tolyl-1H-pyrazol-4-yl)-[3-(1-methanesulfonyl-piperidin-4-yl)-phenyl]-methanone
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Tyrosine-protein kinase BTK | polymer | 274 | 31827.5 | 1 | UniProt (Q06187) Pfam (PF07714) | Homo sapiens (human) | Agammaglobulinaemia tyrosine kinase, ATK, B-cell progenitor kinase, BPK, Bruton tyrosine kinase |
| 2 | B (A) | [5-amino-1-(2-methylphenyl)-1H-pyrazol-4-yl]{3-[1-(methylsulfonyl)piperidin-4-yl]phenyl}methanone | non-polymer | 438.5 | 1 | Chemie (03C) | |||
| 3 | C (A) | water | water | 18.0 | 72 | Chemie (HOH) |
Sequence modifications
A: 387 - 659 (UniProt: Q06187)
| PDB | External Database | Details |
|---|---|---|
| Gly 386 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 31827.5 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 438.5 | |
| All* | Total formula weight | 32266.1 |
