3PHC

Crystal Structure of Plasmodium falciparum purine nucleoside phosphorylase in complex with DADMe-ImmG

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D, E...	Purine nucleoside phosphorylase	polymer	275	30431.0	6	UniProt (Q8T9Z7) Pfam (PF01048) UniProt (by SIFTS) (Q8I3X4) In PDB	Plasmodium falciparum
2	A, C, E	POTASSIUM ION	non-polymer		39.1	3	Chemie (K)
3	A, B, C, D, E...	PHOSPHATE ION	non-polymer		95.0	6	Chemie (PO4)
4	A, B, C, D, E...	2-amino-7-{[(3R,4R)-3-hydroxy-4-(hydroxymethyl)pyrrolidin-1-yl]methyl}-3,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one	non-polymer		279.3	6	Chemie (IM5)
5		water	water		18.0	312	Chemie (HOH)

Sequence modifications

A, B, C, D, E, F: 0 - 245 (UniProt: Q8T9Z7)

PDB	External Database	Details
Leu 1	-	expression tag
Lys 246	-	expression tag
Gly 247	-	expression tag
Glu 248	-	expression tag
Phe 249	-	expression tag
Glu 250	-	expression tag
Ala 251	-	expression tag
Tyr 252	-	expression tag
Val 253	-	expression tag
Glu 254	-	expression tag
Gln 255	-	expression tag
Lys 256	-	expression tag
Leu 257	-	expression tag
Ile 258	-	expression tag
Ser 259	-	expression tag
Glu 260	-	expression tag
Glu 261	-	expression tag
Asp 262	-	expression tag
Leu 263	-	expression tag
Asn 264	-	expression tag
Ser 265	-	expression tag
Ala 266	-	expression tag
Val 267	-	expression tag
Asp 268	-	expression tag
His 269	-	expression tag
His 270	-	expression tag
His 271	-	expression tag
His 272	-	expression tag
His 273	-	expression tag
His 274	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	6
	Total formula weight	182585.8
Non-Polymers*	Number of molecules	15
	Total formula weight	2362.9
All*	Total formula weight	184948.7

*Water molecules are not included.