3PEH

Crystal Structure of the N-terminal domain of an HSP90 from Plasmodium Falciparum, PFL1070c in the presence of a thienopyrimidine derivative

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Endoplasmin homolog	polymer	281	32065.3	2	UniProt (Q8I0V4) Pfam (PF13589)	Plasmodium falciparum 3D7
2	C, E (A, B)	2-amino-4-{2,4-dichloro-5-[2-(diethylamino)ethoxy]phenyl}-N-ethylthieno[2,3-d]pyrimidine-6-carboxamide	non-polymer		482.4	2	Chemie (IBD)
3	D, F (A, B)	SULFATE ION	non-polymer		96.1	2	Chemie (SO4)

Sequence modifications

A, B: 68 - 330 (UniProt: Q8I0V4)

PDB	External Database	Details
Met 50	-	expression tag
His 51	-	expression tag
His 52	-	expression tag
His 53	-	expression tag
His 54	-	expression tag
His 55	-	expression tag
His 56	-	expression tag
Ser 57	-	expression tag
Ser 58	-	expression tag
Gly 59	-	expression tag
Arg 60	-	expression tag
Glu 61	-	expression tag
Asn 62	-	expression tag
Leu 63	-	expression tag
Tyr 64	-	expression tag
Phe 65	-	expression tag
Gln 66	-	expression tag
Gly 67	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	64130.6
Non-Polymers*	Number of molecules	4
	Total formula weight	1157.0
All*	Total formula weight	65287.6

*Water molecules are not included.