3PDS

Irreversible Agonist-Beta2 Adrenoceptor Complex

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Fusion protein Beta-2 adrenergic receptor/Lysozyme	polymer	458	52453.3	1	UniProt (P07550) UniProt (P00720) Pfam (PF00001) Pfam (PF00959) In PDB	Homo sapiens (human)	Beta-2 adrenoreceptor, Beta-2 adrenoceptor
2	A	8-hydroxy-5-[(1R)-1-hydroxy-2-({2-[3-methoxy-4-(3-sulfanylpropoxy)phenyl]ethyl}amino)ethyl]quinolin-2(1H)-one	non-polymer		444.5	1	Chemie (ERC)		Endolysin, Lysis protein, Muramidase
3	A	CHOLESTEROL	non-polymer		386.7	1	Chemie (CLR)		Beta-2 adrenoreceptor, Beta-2 adrenoceptor
4	A	SULFATE ION	non-polymer		96.1	6	Chemie (SO4)

Sequence modifications

A: 25 - 230 (UniProt: P07550)

PDB	External Database	Details
Gln 27	Glu 27	conflict
Cys 93	His 93	engineered mutation
Glu 187	Asn 187	engineered mutation

A: 1002 - 263 (UniProt: P00720)

PDB	External Database	Details
Thr 1054	Cys 54	engineered mutation
Ala 1097	Cys 97	conflict

A: 264 - 348 (UniProt: P07550)

PDB	External Database	Details
His 349	-	expression tag
His 350	-	expression tag
His 351	-	expression tag
His 352	-	expression tag
His 353	-	expression tag
His 354	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	52453.3
Non-Polymers*	Number of molecules	8
	Total formula weight	1407.6
All*	Total formula weight	53860.8

*Water molecules are not included.