3PC8
X-ray crystal structure of the heterodimeric complex of XRCC1 and DNA ligase III-alpha BRCT domains.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | DNA repair protein XRCC1 | polymer | 98 | 11753.3 | 2 | UniProt (Q60596) Pfam (PF16589) | Mus musculus (mouse) | X-ray repair cross-complementing protein 1 |
| 2 | C, D (C, D) | DNA ligase 3 | polymer | 88 | 9953.3 | 2 | UniProt (P49916) Pfam (PF16759) | Homo sapiens (human) | DNA ligase III, Polydeoxyribonucleotide synthase [ATP] 3 |
| 3 | E (B) | MAGNESIUM ION | non-polymer | 24.3 | 1 | Chemie (MG) | |||
| 4 | F (D) | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL | non-polymer | 122.1 | 1 | Chemie (TRS) | |||
| 5 | G, H, I, J (A, B, C, D) | water | water | 18.0 | 208 | Chemie (HOH) |
Sequence modifications
A, B: 534 - 631 (UniProt: Q60596)
C, D: 837 - 921 (UniProt: P49916)
| PDB | External Database | Details |
|---|---|---|
| Met 534 | Ile 534 | engineered mutation |
| Arg 574 | Tyr 574 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Gly 835 | - | expression tag |
| Ser 836 | - | expression tag |
| Ser 842 | Cys 929 | engineered mutation |
| Ser 922 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 43413.2 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 146.4 | |
| All* | Total formula weight | 43559.6 |
