3PBL

Structure of the human dopamine D3 receptor in complex with eticlopride

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	D(3) dopamine receptor, Lysozyme chimera	polymer	481	53653.0	2	UniProt (P35462) UniProt (P00720) Pfam (PF00001) Pfam (PF00959) In PDB	Homo sapiens (human Bacteriophage T4)	Dopamine D3 receptor, Endolysin, Lysis protein, Muramidase
2	C, D	alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose	branched		342.3	2	In PDB BIRD (PRD_900001) GlyTouCan (G07411ON)		alpha-maltose
3	A, B	3-chloro-5-ethyl-N-{[(2S)-1-ethylpyrrolidin-2-yl]methyl}-6-hydroxy-2-methoxybenzamide	non-polymer		340.8	2	Chemie (ETQ)

Sequence modifications

A, B: 2 - 221 (UniProt: P35462)

PDB	External Database	Details
Asp -8	-	expression tag
Tyr -7	-	expression tag
Lys -6	-	expression tag
Asp -5	-	expression tag
Asp -4	-	expression tag
Asp -3	-	expression tag
Asp -2	-	expression tag
Gly -1	-	expression tag
Ala 0	-	expression tag
Pro 1	-	expression tag
Trp 119	Leu 119	engineered mutation

A, B: 1002 - 1161 (UniProt: P00720)

PDB	External Database	Details
Thr 1054	Cys 54	engineered mutation
Ala 1097	Cys 97	engineered mutation

A, B: 319 - 400 (UniProt: P35462)

PDB	External Database	Details
Gly 401	-	expression tag
Arg 402	-	expression tag
Pro 403	-	expression tag
Leu 404	-	expression tag
Glu 405	-	expression tag
Val 406	-	expression tag
Leu 407	-	expression tag
Phe 408	-	expression tag
Gln 409	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	107306.1
Branched	Number of molecules	2
	Total formula weight	684.6
Non-Polymers*	Number of molecules	2
	Total formula weight	681.7
All*	Total formula weight	108672.4

*Water molecules are not included.