3P9J
Aurora A kinase domain with phthalazinone pyrazole inhibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Serine/threonine-protein kinase 6 | polymer | 268 | 31047.7 | 1 | UniProt (O14965) Pfam (PF00069) | Homo sapiens (human) | Aurora kinase A, Aurora/IPL1-related kinase 1, ARK-1, Aurora-related kinase 1, hARK1, Breast tumor-amplified kinase, Serine/threonine-protein kinase 15, Serine/threonine-protein kinase aurora-A |
| 2 | B (A) | 4-[(5-methyl-1H-pyrazol-3-yl)amino]-2-phenylphthalazin-1(2H)-one | non-polymer | 317.3 | 1 | Chemie (P9J) | |||
| 3 | C (A) | water | water | 18.0 | 19 | Chemie (HOH) |
Sequence modifications
A: 125 - 391 (UniProt: O14965)
| PDB | External Database | Details |
|---|---|---|
| Ala 124 | - | expression tag |
| Ala 287 | Thr 287 | engineered mutation |
| Ala 288 | Thr 288 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 31047.7 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 317.3 | |
| All* | Total formula weight | 31365.1 |
