3P71
Crystal structure of the complex of LCMT-1 and PP2A
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | T | Leucine carboxyl methyltransferase 1 | polymer | 334 | 38504.2 | 1 | UniProt (Q9UIC8) Pfam (PF04072) In PDB | Homo sapiens (human) | Protein-leucine O-methyltransferase |
| 2 | C | Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform | polymer | 304 | 35038.5 | 1 | UniProt (P67775) Pfam (PF00149) In PDB | Homo sapiens (human) | PP2A-alpha, Replication protein C, RP-C |
| 3 | T | DI(HYDROXYETHYL)ETHER | non-polymer | 106.1 | 1 | Chemie (PEG) | |||
| 4 | C | 5'-{[(3S)-3-amino-3-carboxypropyl](ethyl)amino}-5'-deoxyadenosine | non-polymer | 395.4 | 1 | Chemie (AN6) | |||
| 5 | C | MANGANESE (II) ION | non-polymer | 54.9 | 2 | Chemie (MN) | |||
| 6 | water | water | 18.0 | 120 | Chemie (HOH) |
Sequence modifications
T: 1 - 334 (UniProt: Q9UIC8)
C: 1 - 309 (UniProt: P67775)
| PDB | External Database | Details |
|---|---|---|
| Met 19 | Cys 19 | engineered mutation |
| Glu 21 | Ala 21 | engineered mutation |
| Asn 22 | Asp 22 | engineered mutation |
| Ser 115 | Pro 115 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| - | Arg 294 | deletion |
| - | Arg 295 | deletion |
| - | Gly 296 | deletion |
| - | Glu 297 | deletion |
| - | Pro 298 | deletion |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 73542.7 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 611.4 | |
| All* | Total formula weight | 74154.1 |
