3P1Q
Crystal structure of human 14-3-3 sigma C38N/N166H in complex with TASK-3 Peptide and stabilizer fusicoccin A
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | 14-3-3 protein sigma | polymer | 236 | 26577.9 | 1 | UniProt (P31947) Pfam (PF00244) | Homo sapiens (human) | Stratifin, Epithelial cell marker protein 1 |
| 2 | B (P) | 6-mer peptide from Potassium channel subfamily K member 9 | polymer | 6 | 857.0 | 1 | UniProt (Q9NPC2) | TASK-3 peptide | |
| 3 | C (A) | FUSICOCCIN | non-polymer | 680.8 | 1 | Chemie (FSC) PubChem (46936214) PubChem (24124005) PubChem (44201245) PubChem (52940549) PubChem (57061783) PubChem (58892803) PubChem (143471529) PubChem (270757) PubChem (71308204) PubChem (447573) PubChem (89352860) PubChem (89424149) PubChem (5381214) PubChem (124914704) PubChem (124914702) PubChem (125183286) PubChem (134693211) PubChem (12309993) PubChem (138107212) PubChem (89167108) PubChem (89358776) PubChem (91305733) PubChem (146157920) PubChem (163008024) PubChem (124914703) PubChem (124914705) PubChem (6437071) PubChem (134688043) PubChem (11534864) PubChem (163008025) PubChem (163728719) | |||
| 4 | D (A) | CHLORIDE ION | non-polymer | 35.5 | 1 | Chemie (CL) PubChem (312) | |||
| 5 | E, F (A) | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) PubChem (888) | |||
| 6 | G (A) | CALCIUM ION | non-polymer | 40.1 | 1 | Chemie (CA) PubChem (271) | |||
| 7 | H, I (A, P) | water | water | 18.0 | 204 | Chemie (HOH) |
Sequence modifications
A: 1 - 231 (UniProt: P31947)
| PDB | External Database | Details |
|---|---|---|
| Gly -4 | - | expression tag |
| Ala -3 | - | expression tag |
| Met -2 | - | expression tag |
| Gly -1 | - | expression tag |
| Ser 0 | - | expression tag |
| Asn 38 | Cys 38 | engineered mutation |
| His 166 | Asn 166 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 27434.9 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 805.0 | |
| All* | Total formula weight | 28239.8 |
