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3P0P

Human Tankyrase 2 - Catalytic PARP domain in complex with an inhibitor

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A, CTankyrase-2polymer24027299.82UniProt (Q9H2K2)
Pfam (PF00644)
In PDB
Homo sapiens (human)Poly(ADP-ribose) polymerase, TANK2, Tankyrase II, TNKS-2, TRF1-interacting ankyrin-related ADP-ribose polymerase 2, Tankyrase-like protein, Tankyrase-related protein, Poly [ADP-ribose] polymerase 5B
2A, CZINC IONnon-polymer65.42Chemie (ZN)
3A, C2-[4-(4-fluorophenyl)piperazin-1-yl]-6-methylpyrimidin-4(3H)-onenon-polymer288.32Chemie (NNF)
4A, CSULFATE IONnon-polymer96.14Chemie (SO4)
5waterwater18.0115Chemie (HOH)
Sequence modifications
A, C: 946 - 1162 (UniProt: Q9H2K2)
PDBExternal DatabaseDetails
Met 923-expression tag
His 924-expression tag
His 925-expression tag
His 926-expression tag
His 927-expression tag
His 928-expression tag
His 929-expression tag
Ser 930-expression tag
Ser 931-expression tag
Gly 932-expression tag
Val 933-expression tag
Asp 934-expression tag
Leu 935-expression tag
Gly 936-expression tag
Thr 937-expression tag
Glu 938-expression tag
Asn 939-expression tag
Leu 940-expression tag
Tyr 941-expression tag
Phe 942-expression tag
Gln 943-expression tag
Ser 944-expression tag
Met 945-expression tag
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains2
Total formula weight54599.5
Non-Polymers*Number of molecules8
Total formula weight1091.7
All*Total formula weight55691.2
*Water molecules are not included.

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PDB entries from 2024-06-12

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