3OZG

Crystal Structure of Plasmodium falciparum Hypoxanthine-Guanine-Xanthine Phosphoribosyltransferase in complex with S-SerMe-ImmH phosphonate

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D (A, B, C, D)	Hypoxanthine-guanine-xanthine phosphoribosyltransferase	polymer	250	28410.7	4	UniProt (P20035) Pfam (PF00156)	Plasmodium falciparum FCR-3/Gambia	HGXPRTase, HGXPRT, HGPRT
2	E, I, K, N (A, B, C, D)	[(3S)-4-hydroxy-3-{[(4-oxo-4,5-dihydro-3H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]amino}butyl]phosphonic acid	non-polymer		316.3	4	Chemie (SSI)
3	F, J, L, O (A, B, C, D)	PYROPHOSPHATE 2-	non-polymer		176.0	4	Chemie (POP)
4	G, H, M, P (A, B, C, D)	MAGNESIUM ION	non-polymer		24.3	4	Chemie (MG)
5	Q, R, S, T (A, B, C, D)	water	water		18.0	211	Chemie (HOH)

Sequence modifications

A, B, C, D: 1 - 231 (UniProt: P20035)

PDB	External Database	Details
Met -18	-	expression tag
Gly -17	-	expression tag
Gly -16	-	expression tag
Ser -15	-	expression tag
His -14	-	expression tag
His -13	-	expression tag
His -12	-	expression tag
His -11	-	expression tag
His -10	-	expression tag
His -9	-	expression tag
Gly -8	-	expression tag
Gly -7	-	expression tag
Leu -6	-	expression tag
Val -5	-	expression tag
Pro -4	-	expression tag
Arg -3	-	expression tag
Gly -2	-	expression tag
Ser -1	-	expression tag
His 0	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	113642.8
Non-Polymers*	Number of molecules	12
	Total formula weight	2066.1
All*	Total formula weight	115708.8

*Water molecules are not included.