3OW3

Discovery of dihydrothieno- and dihydrofuropyrimidines as potent pan Akt inhibitors

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	cAMP-dependent protein kinase catalytic subunit alpha	polymer	350	40657.3	1	UniProt (P05132) Pfam (PF00069) In PDB	Mus musculus (mouse)	PKA C-alpha
2	B	cAMP-dependent protein kinase inhibitor alpha	polymer	20	2226.4	1	UniProt (P63248) In PDB	Mus musculus	PKI-alpha, cAMP-dependent protein kinase inhibitor, muscle/brain isoform
3	A	(2R)-3-(1H-indol-3-yl)-1-{4-[(5S)-5-methyl-5,7-dihydrothieno[3,4-d]pyrimidin-4-yl]piperazin-1-yl}-1-oxopropan-2-amine	non-polymer		422.5	1	Chemie (SMY)
4		water	water		18.0	403	Chemie (HOH)

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	42883.7
Non-Polymers*	Number of molecules	1
	Total formula weight	422.5
All*	Total formula weight	43306.3

*Water molecules are not included.