3OW2
Crystal Structure of Enhanced Macrolide Bound to 50S Ribosomal Subunit
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | 0 | 23S RIBOSOMAL RNA | polymer | 2902 | 939691.4 | 1 | GenBank (3377779) | Haloarcula marismortui | |
| 2 | 9 | 5S RIBOSOMAL RNA | polymer | 122 | 39318.4 | 1 | GenBank (3377779) | Haloarcula marismortui | |
| 3 | A | 50S ribosomal protein L2P | polymer | 237 | 24994.3 | 1 | UniProt (P20276) Pfam (PF00181) Pfam (PF03947) In PDB | Haloarcula marismortui | |
| 4 | B | 50S ribosomal protein L3P | polymer | 337 | 37265.2 | 1 | UniProt (P20279) Pfam (PF00297) In PDB | Haloarcula marismortui | |
| 5 | C | 50S ribosomal protein L4P | polymer | 246 | 26442.1 | 1 | UniProt (P12735) Pfam (PF00573) In PDB | Haloarcula marismortui | |
| 6 | D | 50S ribosomal protein L5P | polymer | 165 | 18368.6 | 1 | UniProt (P14124) Pfam (PF00281) Pfam (PF00673) In PDB | Haloarcula marismortui | |
| 7 | E | 50S ribosomal protein L6P | polymer | 172 | 19316.0 | 1 | UniProt (P14135) Pfam (PF00347) In PDB | Haloarcula marismortui | |
| 8 | F | 50S ribosomal protein L7Ae | polymer | 119 | 12600.8 | 1 | UniProt (P12743) Pfam (PF01248) In PDB | Haloarcula marismortui | |
| 9 | G | 50S ribosomal protein L10E | polymer | 62 | 7101.0 | 1 | UniProt (P15825) Pfam (PF00466) In PDB | Haloarcula marismortui | |
| 10 | H | 50S ribosomal protein L10e | polymer | 167 | 18022.5 | 1 | Pfam (PF00252) UniProt (by SIFTS) (A0A0X1KGB2) In PDB | Haloarcula marismortui | |
| 11 | I | 50S ribosomal protein L13P | polymer | 142 | 15931.8 | 1 | UniProt (P29198) Pfam (PF00572) In PDB | Haloarcula marismortui | |
| 12 | J | 50S ribosomal protein L14P | polymer | 132 | 14216.2 | 1 | UniProt (P22450) Pfam (PF00238) In PDB | Haloarcula marismortui | |
| 13 | K | 50S ribosomal protein L15P | polymer | 150 | 16368.8 | 1 | UniProt (P12737) Pfam (PF00828) In PDB | Haloarcula marismortui | |
| 14 | L | 50S ribosomal protein L15e | polymer | 194 | 22856.6 | 1 | Pfam (PF00827) UniProt (by SIFTS) (A0A0X1KGB3) In PDB | Haloarcula marismortui | |
| 15 | M | 50S ribosomal protein L18P | polymer | 186 | 20509.7 | 1 | UniProt (P14123) Pfam (PF17144) In PDB | Haloarcula marismortui | |
| 16 | N | 50S ribosomal protein L18e | polymer | 115 | 12307.7 | 1 | UniProt (P12733) Pfam (PF00828) In PDB | Haloarcula marismortui | |
| 17 | O | 50S ribosomal protein L19e | polymer | 143 | 16135.9 | 1 | UniProt (P14119) Pfam (PF01280) In PDB | Haloarcula marismortui | |
| 18 | P | 50S ribosomal protein L21e | polymer | 95 | 10436.6 | 1 | UniProt (P12734) Pfam (PF01157) In PDB | Haloarcula marismortui | |
| 19 | Q | 50S ribosomal protein L22P | polymer | 150 | 16363.3 | 1 | UniProt (P10970) Pfam (PF00237) In PDB | Haloarcula marismortui | |
| 20 | R | 50S ribosomal protein L23P | polymer | 81 | 9178.0 | 1 | UniProt (P12732) Pfam (PF00276) In PDB | Haloarcula marismortui | |
| 21 | S | 50S ribosomal protein L24P | polymer | 119 | 13539.8 | 1 | UniProt (P10972) Pfam (PF16906) Pfam (PF00467) In PDB | Haloarcula marismortui | |
| 22 | T | 50S ribosomal protein L24e | polymer | 53 | 5919.4 | 1 | UniProt (P14116) Pfam (PF01246) In PDB | Haloarcula marismortui | |
| 23 | U | 50S ribosomal protein L29P | polymer | 65 | 7145.1 | 1 | UniProt (P10971) Pfam (PF00831) In PDB | Haloarcula marismortui | |
| 24 | V | 50S ribosomal protein L30P | polymer | 154 | 17062.9 | 1 | UniProt (P14121) Pfam (PF00327) In PDB | Haloarcula marismortui | |
| 25 | W | 50S ribosomal protein L31e | polymer | 82 | 9315.5 | 1 | UniProt (P18138) Pfam (PF01198) In PDB | Haloarcula marismortui | |
| 26 | X | 50S ribosomal protein L32e | polymer | 142 | 16079.0 | 1 | UniProt (P12736) Pfam (PF01655) In PDB | Haloarcula marismortui | |
| 27 | Y | 50S ribosomal protein L37Ae | polymer | 73 | 8097.8 | 1 | Pfam (PF01780) UniProt (by SIFTS) (A0A0X1KGB4) In PDB | Haloarcula marismortui | |
| 28 | Z | 50S ribosomal protein L37e | polymer | 56 | 6199.0 | 1 | UniProt (P32410) Pfam (PF01907) In PDB | Haloarcula marismortui | |
| 29 | 1 | 50S ribosomal protein L39e | polymer | 48 | 5844.7 | 1 | UniProt (P22452) Pfam (PF00832) In PDB | Haloarcula marismortui | |
| 30 | 2 | 50S ribosomal protein L44E | polymer | 92 | 10815.2 | 1 | UniProt (P32411) Pfam (PF00935) In PDB | Haloarcula marismortui | |
| 31 | 0, J, K, 9, S... | MAGNESIUM ION | non-polymer | 24.3 | 61 | Chemie (MG) | |||
| 32 | 0 | POTASSIUM ION | non-polymer | 39.1 | 1 | Chemie (K) | |||
| 33 | 0, I, L, P, Q... | SODIUM ION | non-polymer | 23.0 | 26 | Chemie (NA) | |||
| 34 | 0, I, L, N, Q... | CHLORIDE ION | non-polymer | 35.5 | 13 | Chemie (CL) | |||
| 35 | 0, F, 9, Q, R... | STRONTIUM ION | non-polymer | 87.6 | 98 | Chemie (SR) | |||
| 36 | 0 | (2R,3S,4R,5R,8R,10R,11R,12S,13S,14R)-2-ethyl-3,4,10-trihydroxy-3,5,6,8,10,12,14-heptamethyl-15-oxo-11-[(3,4,6-trideoxy-3-{[3-(1-{(1S,2R)-1-(fluoromethyl)-2-hydroxy-2-[4-(methylsulfonyl)phenyl]ethyl}-1H-1,2,3-triazol-4-yl)propyl](methyl)amino}-beta-D-xylo-hexopyranosyl)oxy]-1-oxa-6-azacyclopentadecan-13-yl 2,6-dideoxy-3-C-methyl-3-O-methyl-alpha-L-ribo-hexopyranoside | non-polymer | 1074.3 | 1 | Chemie (EMK) | |||
| 37 | T, Y, Z, 2 | CADMIUM ION | non-polymer | 112.4 | 4 | Chemie (CD) |
Sequence modifications
0: 10 - 2914 (GenBank: 3377779)
O: 1 - 143 (UniProt: P14119)
| PDB | External Database | Details |
|---|---|---|
| - | U 2716 | DELETION |
| - | C 2717 | DELETION |
| C 560 | U 3155 | CONFLICT |
| A 2099 | G 4693 | CONFLICT |
| PDB | External Database | Details |
|---|---|---|
| Lys 71 | Tyr 71 | CONFLICT |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 30 |
| Total formula weight | 1397443.3 | |
| Non-Polymers* | Number of molecules | 204 |
| Total formula weight | 12691.1 | |
| All* | Total formula weight | 1410134.4 |
