3OW2
Crystal Structure of Enhanced Macrolide Bound to 50S Ribosomal Subunit
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (0) | 23S RIBOSOMAL RNA | polymer | 2902 | 939691.4 | 1 | GenBank (3377779) | Haloarcula marismortui | |
| 2 | B (9) | 5S RIBOSOMAL RNA | polymer | 122 | 39318.4 | 1 | GenBank (3377779) | Haloarcula marismortui | |
| 3 | C (A) | 50S ribosomal protein L2P | polymer | 237 | 24994.3 | 1 | UniProt (P20276) Pfam (PF00181) Pfam (PF03947) | Haloarcula marismortui | |
| 4 | D (B) | 50S ribosomal protein L3P | polymer | 337 | 37265.2 | 1 | UniProt (P20279) Pfam (PF00297) | Haloarcula marismortui | |
| 5 | E (C) | 50S ribosomal protein L4P | polymer | 246 | 26442.1 | 1 | UniProt (P12735) Pfam (PF00573) | Haloarcula marismortui | |
| 6 | F (D) | 50S ribosomal protein L5P | polymer | 165 | 18368.6 | 1 | UniProt (P14124) Pfam (PF00281) Pfam (PF00673) | Haloarcula marismortui | |
| 7 | G (E) | 50S ribosomal protein L6P | polymer | 172 | 19316.0 | 1 | UniProt (P14135) Pfam (PF00347) | Haloarcula marismortui | |
| 8 | H (F) | 50S ribosomal protein L7Ae | polymer | 119 | 12600.8 | 1 | UniProt (P12743) Pfam (PF01248) | Haloarcula marismortui | |
| 9 | I (G) | 50S ribosomal protein L10E | polymer | 62 | 7101.0 | 1 | UniProt (P15825) Pfam (PF00466) | Haloarcula marismortui | |
| 10 | J (H) | 50S ribosomal protein L10e | polymer | 167 | 18022.5 | 1 | Pfam (PF00252) UniProt (by SIFTS) (A0A0X1KGB2) | Haloarcula marismortui | |
| 11 | K (I) | 50S ribosomal protein L13P | polymer | 142 | 15931.8 | 1 | UniProt (P29198) Pfam (PF00572) | Haloarcula marismortui | |
| 12 | L (J) | 50S ribosomal protein L14P | polymer | 132 | 14216.2 | 1 | UniProt (P22450) Pfam (PF00238) | Haloarcula marismortui | |
| 13 | M (K) | 50S ribosomal protein L15P | polymer | 150 | 16368.8 | 1 | UniProt (P12737) Pfam (PF00828) | Haloarcula marismortui | |
| 14 | N (L) | 50S ribosomal protein L15e | polymer | 194 | 22856.6 | 1 | Pfam (PF00827) UniProt (by SIFTS) (A0A0X1KGB3) | Haloarcula marismortui | |
| 15 | O (M) | 50S ribosomal protein L18P | polymer | 186 | 20509.7 | 1 | UniProt (P14123) Pfam (PF17144) | Haloarcula marismortui | |
| 16 | P (N) | 50S ribosomal protein L18e | polymer | 115 | 12307.7 | 1 | UniProt (P12733) Pfam (PF00828) | Haloarcula marismortui | |
| 17 | Q (O) | 50S ribosomal protein L19e | polymer | 143 | 16135.9 | 1 | UniProt (P14119) Pfam (PF01280) | Haloarcula marismortui | |
| 18 | R (P) | 50S ribosomal protein L21e | polymer | 95 | 10436.6 | 1 | UniProt (P12734) Pfam (PF01157) | Haloarcula marismortui | |
| 19 | S (Q) | 50S ribosomal protein L22P | polymer | 150 | 16363.3 | 1 | UniProt (P10970) Pfam (PF00237) | Haloarcula marismortui | |
| 20 | T (R) | 50S ribosomal protein L23P | polymer | 81 | 9178.0 | 1 | UniProt (P12732) Pfam (PF00276) | Haloarcula marismortui | |
| 21 | U (S) | 50S ribosomal protein L24P | polymer | 119 | 13539.8 | 1 | UniProt (P10972) Pfam (PF16906) Pfam (PF00467) | Haloarcula marismortui | |
| 22 | V (T) | 50S ribosomal protein L24e | polymer | 53 | 5919.4 | 1 | UniProt (P14116) Pfam (PF01246) | Haloarcula marismortui | |
| 23 | W (U) | 50S ribosomal protein L29P | polymer | 65 | 7145.1 | 1 | UniProt (P10971) Pfam (PF00831) | Haloarcula marismortui | |
| 24 | X (V) | 50S ribosomal protein L30P | polymer | 154 | 17062.9 | 1 | UniProt (P14121) Pfam (PF00327) | Haloarcula marismortui | |
| 25 | Y (W) | 50S ribosomal protein L31e | polymer | 82 | 9315.5 | 1 | UniProt (P18138) Pfam (PF01198) | Haloarcula marismortui | |
| 26 | Z (X) | 50S ribosomal protein L32e | polymer | 142 | 16079.0 | 1 | UniProt (P12736) Pfam (PF01655) | Haloarcula marismortui | |
| 27 | AA (Y) | 50S ribosomal protein L37Ae | polymer | 73 | 8097.8 | 1 | Pfam (PF01780) UniProt (by SIFTS) (A0A0X1KGB4) | Haloarcula marismortui | |
| 28 | BA (Z) | 50S ribosomal protein L37e | polymer | 56 | 6199.0 | 1 | UniProt (P32410) Pfam (PF01907) | Haloarcula marismortui | |
| 29 | CA (1) | 50S ribosomal protein L39e | polymer | 48 | 5844.7 | 1 | UniProt (P22452) Pfam (PF00832) | Haloarcula marismortui | |
| 30 | DA (2) | 50S ribosomal protein L44E | polymer | 92 | 10815.2 | 1 | UniProt (P32411) Pfam (PF00935) | Haloarcula marismortui | |
| 31 | AB, AC, BB, BC, CB... (0, J, K, 9, S...) | MAGNESIUM ION | non-polymer | 24.3 | 61 | Chemie (MG) | |||
| 32 | HC (0) | POTASSIUM ION | non-polymer | 39.1 | 1 | Chemie (K) | |||
| 33 | AD, BH, GH, IC, JC... (0, I, L, P, Q...) | SODIUM ION | non-polymer | 23.0 | 26 | Chemie (NA) | |||
| 34 | BD, CD, CH, DD, DH... (0, I, L, N, Q...) | CHLORIDE ION | non-polymer | 35.5 | 13 | Chemie (CL) | |||
| 35 | AE, AF, AG, AH, BE... (0, F, 9, Q, R...) | STRONTIUM ION | non-polymer | 87.6 | 98 | Chemie (SR) | |||
| 36 | KG (0) | (2R,3S,4R,5R,8R,10R,11R,12S,13S,14R)-2-ethyl-3,4,10-trihydroxy-3,5,6,8,10,12,14-heptamethyl-15-oxo-11-[(3,4,6-trideoxy-3-{[3-(1-{(1S,2R)-1-(fluoromethyl)-2-hydroxy-2-[4-(methylsulfonyl)phenyl]ethyl}-1H-1,2,3-triazol-4-yl)propyl](methyl)amino}-beta-D-xylo-hexopyranosyl)oxy]-1-oxa-6-azacyclopentadecan-13-yl 2,6-dideoxy-3-C-methyl-3-O-methyl-alpha-L-ribo-hexopyranoside | non-polymer | 1074.3 | 1 | Chemie (EMK) | |||
| 37 | QH, TH, UH, XH (T, Y, Z, 2) | CADMIUM ION | non-polymer | 112.4 | 4 | Chemie (CD) |
Sequence modifications
0: 10 - 2914 (GenBank: 3377779)
O: 1 - 143 (UniProt: P14119)
| PDB | External Database | Details |
|---|---|---|
| - | U 2716 | deletion |
| - | C 2717 | deletion |
| C 560 | U 3155 | conflict |
| A 2099 | G 4693 | conflict |
| PDB | External Database | Details |
|---|---|---|
| Lys 71 | Tyr 71 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 30 |
| Total formula weight | 1397443.3 | |
| Non-Polymers* | Number of molecules | 204 |
| Total formula weight | 12691.1 | |
| All* | Total formula weight | 1410134.4 |
