3OS8

Estrogen Receptor

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Estrogen receptor	polymer	258	29541.7	2	UniProt (P03372) Pfam (PF00104)	Homo sapiens (human)	ER, ER-alpha, Estradiol receptor, Nuclear receptor subfamily 3 group A member 1
2	C, D (C, D)	Estrogen receptor	polymer	258	29465.6	2	UniProt (P03372) Pfam (PF00104)	Homo sapiens (human)	ER, ER-alpha, Estradiol receptor, Nuclear receptor subfamily 3 group A member 1
3	E, F, G, H (A, B, C, D)	4-[1-benzyl-7-(trifluoromethyl)-1H-indazol-3-yl]benzene-1,3-diol	non-polymer		384.4	4	Chemie (KN0)
4	I, J, K, L (A, B, C, D)	water	water		18.0	267	Chemie (HOH)

Sequence modifications

A, B: 299 - 553 (UniProt: P03372)

PDB	External Database	Details
Ser 296	-	expression tag
Asn 297	-	expression tag
Ala 298	-	expression tag
Arg 372	Leu 372	engineered mutation
Ser 536	Leu 536	engineered mutation

C, D: 299 - 553 (UniProt: P03372)

PDB	External Database	Details
Ser 296	-	expression tag
Asn 297	-	expression tag
Ala 298	-	expression tag
Arg 372	Leu 372	engineered mutation
Ser 536	Leu 536	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	118014.7
Non-Polymers*	Number of molecules	4
	Total formula weight	1537.4
All*	Total formula weight	119552.1

*Water molecules are not included.