3OPE
Structural Basis of Auto-inhibitory mechanism of Histone methyltransferase
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Probable histone-lysine N-methyltransferase ASH1L | polymer | 222 | 25686.1 | 2 | UniProt (Q9NR48) Pfam (PF17907) Pfam (PF00856) | Homo sapiens (human) | Absent small and homeotic disks protein 1 homolog, ASH1-like protein, huASH1, Lysine N-methyltransferase 2H |
| 2 | C, D, E, G, H... (A, B) | ZINC ION | non-polymer | 65.4 | 6 | Chemie (ZN) | |||
| 3 | F, J (A, B) | S-ADENOSYLMETHIONINE | non-polymer | 398.4 | 2 | Chemie (SAM) PubChem (5136) PubChem (34755) PubChem (58633578) PubChem (60038769) PubChem (58766358) PubChem (73897310) PubChem (9865603) PubChem (87224684) PubChem (12312798) PubChem (131697735) PubChem (145712080) PubChem (132988922) PubChem (134692588) PubChem (135030730) PubChem (140459785) PubChem (163046094) | |||
| 4 | K, L (A, B) | water | water | 18.0 | 27 | Chemie (HOH) |
Sequence modifications
A, B: 2069 - 2288 (UniProt: Q9NR48)
| PDB | External Database | Details |
|---|---|---|
| Gly 2067 | - | expression tag |
| Ser 2068 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 51372.2 | |
| Non-Polymers* | Number of molecules | 8 |
| Total formula weight | 1189.3 | |
| All* | Total formula weight | 52561.6 |
