3OGP
Crystal Structure of 6s-98S FIV Protease with Darunavir bound
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | FIV Protease | polymer | 116 | 13228.3 | 2 | UniProt (P16088) Pfam (PF00077) | Feline immunodeficiency virus (FIV) | Protease, Retropepsin |
| 2 | C, E (A, B) | (3R,3AS,6AR)-HEXAHYDROFURO[2,3-B]FURAN-3-YL(1S,2R)-3-[[(4-AMINOPHENYL)SULFONYL](ISOBUTYL)AMINO]-1-BENZYL-2-HYDROXYPROPYLCARBAMATE | non-polymer | 547.7 | 2 | Chemie (017) PubChem (23545473) PubChem (44400512) PubChem (44578485) PubChem (66725685) PubChem (3001874) PubChem (89394603) PubChem (102206609) PubChem (6320435) PubChem (52949690) PubChem (125136514) PubChem (58330571) PubChem (60170302) PubChem (70329566) PubChem (89334570) PubChem (101897907) PubChem (102206607) PubChem (102206608) PubChem (118243427) PubChem (118243428) PubChem (118243429) PubChem (213039) PubChem (125136515) PubChem (6320436) PubChem (6320437) PubChem (129010372) PubChem (131632443) PubChem (131667685) PubChem (134694394) PubChem (137704505) PubChem (137704865) PubChem (138631483) PubChem (138631484) PubChem (138631622) PubChem (144227995) PubChem (145507139) PubChem (147231834) PubChem (156183881) PubChem (156183911) PubChem (171370671) | |||
| 3 | D (A) | DIMETHYL SULFOXIDE | non-polymer | 78.1 | 1 | Chemie (DMS) PubChem (679) | |||
| 4 | F, G (A, B) | water | water | 18.0 | 158 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 116 (UniProt: P16088)
| PDB | External Database | Details |
|---|---|---|
| Val 37 | Ile 75 | engineered mutation |
| Met 55 | Asn 93 | engineered mutation |
| Ile 59 | Val 97 | engineered mutation |
| Ser 98 | Ile 136 | engineered mutation |
| Val 99 | Gln 137 | engineered mutation |
| Asn 100 | Pro 138 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 26456.6 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 1173.5 | |
| All* | Total formula weight | 27630.0 |
