3OE0
Crystal structure of the CXCR4 chemokine receptor in complex with a cyclic peptide antagonist CVX15
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | C-X-C chemokine receptor type 4, Lysozyme Chimera | polymer | 499 | 56685.5 | 1 | UniProt (P61073) UniProt (P00720) Pfam (PF12109) Pfam (PF00001) Pfam (PF00959) In PDB | Homo Sapiens | CXC-R4, CXCR-4, Stromal cell-derived factor 1 receptor, SDF-1 receptor, Fusin, Leukocyte-derived seven transmembrane domain receptor, LESTR, LCR1, FB22, NPYRL, HM89, Lysis protein, Muramidase, Endolysin |
2 | I | Polyphemusin analog, CXC chemokine receptor antagonist | polymer | 16 | 2139.5 | 1 | BIRD (PRD_001107) | ||
3 | water | water | 18.0 | 6 | Chemie (HOH) |
Sequence modifications
A: 2 - 228 (UniProt: P61073)
A: 1002 - 1161 (UniProt: P00720)
A: 231 - 319 (UniProt: P61073)
PDB | External Database | Details |
---|---|---|
Asp -9 | - | expression tag |
Tyr -8 | - | expression tag |
Lys -7 | - | expression tag |
Asp -6 | - | expression tag |
Asp -5 | - | expression tag |
Asp -4 | - | expression tag |
Asp -3 | - | expression tag |
Ala -2 | - | expression tag |
Gly -1 | - | expression tag |
Ala 0 | - | expression tag |
Pro 1 | - | expression tag |
Trp 125 | Leu 125 | engineered mutation |
PDB | External Database | Details |
---|---|---|
Thr 1054 | Cys 1054 | engineered mutation |
Ala 1097 | Cys 1097 | engineered mutation |
PDB | External Database | Details |
---|---|---|
Ser 1200 | - | linker |
Gly 1201 | - | linker |
Ser 1202 | - | linker |
Pro 240 | Thr 240 | engineered mutation |
Gly 320 | - | expression tag |
Arg 321 | - | expression tag |
Pro 322 | - | expression tag |
Leu 323 | - | expression tag |
Glu 324 | - | expression tag |
Val 325 | - | expression tag |
Leu 326 | - | expression tag |
Phe 327 | - | expression tag |
Gln 328 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 58825.0 | |
All* | Total formula weight | 58825.0 |