3OCB
Akt1 kinase domain with pyrrolopyrimidine inhibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | v-akt murine thymoma viral oncogene homolog 1 (AKT1) | polymer | 341 | 39467.0 | 2 | UniProt (B2RAM5) Pfam (PF00069) Pfam (PF00433) UniProt (by SIFTS) (P31749) | Homo sapiens (human) | |
| 2 | C, D (C, D) | GSK 3 beta peptide | polymer | 10 | 1123.2 | 2 | |||
| 3 | E, F (A, B) | (2S)-2-(4-chlorobenzyl)-3-oxo-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperazin-1-yl]propan-1-amine | non-polymer | 398.9 | 2 | Chemie (XM1) | |||
| 4 | G, H, I, J (A, B, C, D) | water | water | 18.0 | 99 | Chemie (HOH) |
Sequence modifications
A, B: 144 - 480 (UniProt: B2RAM5)
| PDB | External Database | Details |
|---|---|---|
| Gly 140 | - | expression tag |
| Ala 141 | - | expression tag |
| Met 142 | - | expression tag |
| Ala 143 | - | expression tag |
| Asp 473 | Ser 473 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 81180.4 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 797.8 | |
| All* | Total formula weight | 81978.2 |
