3O9W
Recognition of a Glycolipid Antigen by the iNKT Cell TCR
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Antigen-presenting glycoprotein CD1d1 | polymer | 285 | 32632.7 | 1 | UniProt (P11609) Pfam (PF16497) Pfam (PF07654) | Mus musculus (Mouse) | |
| 2 | B (B) | Beta-2-microglobulin | polymer | 99 | 11660.4 | 1 | UniProt (P01887) Pfam (PF07654) | Mus musculus (Mouse) | |
| 3 | C (C) | Valpha14 chimera (Mouse variable domain, Human T-cell receptor alpha chain C region constant domain) | polymer | 209 | 23055.6 | 1 | UniProt (P01848) Pfam (PF09291) | Mus musculus (mouse) | |
| 4 | D (D) | Vbeta8.2 chimera (Mouse variable domain, Human T-cell receptor beta-2 chain C region constant domain) | polymer | 241 | 27027.0 | 1 | UniProt (A0A5B9) Pfam (PF07654) | Mus musculus (mouse) | |
| 5 | E (E) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 1 | In PDB GlyTouCan (G42666HT) | |||
| 6 | F (F) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 570.5 | 1 | In PDB GlyTouCan (G21290RB) | |||
| 7 | G (A) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 1 | Chemie (NAG) | |||
| 8 | H (A) | (2S)-3-(alpha-D-galactopyranosyloxy)-2-(hexadecanoyloxy)propyl (9Z)-octadec-9-enoate | non-polymer | 757.1 | 1 | Chemie (1O2) PubChem (25032479) PubChem (177669147) PubChem (44593354) PubChem (46931128) PubChem (25202268) PubChem (70678950) PubChem (90324291) PubChem (72955714) PubChem (123177764) PubChem (6475756) PubChem (11422817) PubChem (129661863) PubChem (134740331) PubChem (156492533) PubChem (162979109) PubChem (171360955) | |||
| 9 | I, J, K, L (A, B, C, D) | water | water | 18.0 | 53 | Chemie (HOH) |
Sequence modifications
A: 1 - 279 (UniProt: P11609)
C: -1 - 122 (PDB: 3O9W)
C: 123 - 210 (UniProt: P01848)
D: 0 - 129 (PDB: 3O9W)
D: 130 - 240 (UniProt: A0A5B9)
| PDB | External Database | Details |
|---|---|---|
| His 201 | Asp 219 | variant |
| His 280 | - | expression tag |
| His 281 | - | expression tag |
| His 282 | - | expression tag |
| His 283 | - | expression tag |
| His 284 | - | expression tag |
| His 285 | - | expression tag |
C: 123 - 210 (UniProt: P01848)
| PDB | External Database | Details |
|---|---|---|
| Cys 164 | Thr 49 | engineered mutation |
D: 130 - 240 (UniProt: A0A5B9)
| PDB | External Database | Details |
|---|---|---|
| Cys 168 | Ser 56 | engineered mutation |
| Ser 186 | Cys 74 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 94375.6 | |
| Branched | Number of molecules | 2 |
| Total formula weight | 994.9 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 978.3 | |
| All* | Total formula weight | 96348.9 |
