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3O8P

Conformational plasticity of p38 MAP kinase DFG motif mutants in response to inhibitor binding

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1AMitogen-activated protein kinase 14polymer36041285.21UniProt (Q16539)
Pfam (PF00069)
In PDB
Homo sapiensMAP kinase 14, MAPK 14, Mitogen-activated protein kinase p38 alpha, MAP kinase p38 alpha, Cytokine suppressive anti-inflammatory drug-binding protein, CSAID-binding protein, CSBP, MAX-interacting protein 2, MAP kinase MXI2, SAPK2A
2A1-(5-TERT-BUTYL-2-METHYL-2H-PYRAZOL-3-YL)-3-(4-CHLORO-PHENYL)-UREAnon-polymer306.81Chemie (BMU)
3Aoctyl beta-D-glucopyranosidenon-polymer292.41Chemie (BOG)
4A1,2-ETHANEDIOLnon-polymer62.11Chemie (EDO)
5waterwater18.0287Chemie (HOH)
Sequence modifications
A: 1 - 360 (UniProt: Q16539)
PDBExternal DatabaseDetails
Gly 168Asp 168engineered mutation
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains1
Total formula weight41285.2
Non-Polymers*Number of molecules3
Total formula weight661.2
All*Total formula weight41946.4
*Water molecules are not included.

222036

PDB entries from 2024-07-03

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