3O4U
Crystal Structure of HePTP with an Atypically Open WPD Loop
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Tyrosine-protein phosphatase non-receptor type 7 | polymer | 308 | 35232.8 | 1 | UniProt (P35236) Pfam (PF00102) | Homo sapiens (human) | Protein-tyrosine phosphatase LC-PTP, Hematopoietic protein-tyrosine phosphatase, HEPTP |
| 2 | B (A) | L(+)-TARTARIC ACID | non-polymer | 150.1 | 1 | Chemie (TLA) | |||
| 3 | C (A) | S,R MESO-TARTARIC ACID | non-polymer | 150.1 | 1 | Chemie (SRT) | |||
| 4 | D, E (A) | GLYCEROL | non-polymer | 92.1 | 2 | Chemie (GOL) | |||
| 5 | F (A) | water | water | 18.0 | 143 | Chemie (HOH) |
Sequence modifications
A: 44 - 339 (UniProt: P35236)
| PDB | External Database | Details |
|---|---|---|
| Met -11 | - | expression tag |
| Gly -10 | - | expression tag |
| Ser -9 | - | expression tag |
| Asp -8 | - | expression tag |
| Lys -7 | - | expression tag |
| Ile -6 | - | expression tag |
| His -5 | - | expression tag |
| His -4 | - | expression tag |
| His -3 | - | expression tag |
| His -2 | - | expression tag |
| His -1 | - | expression tag |
| His 0 | - | expression tag |
| Asp 72 | Ser 93 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 35232.8 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 484.4 | |
| All* | Total formula weight | 35717.2 |
