3O0U
Cathepsin K covalently bound to a cyano-pyrimidine inhibitor with improved selectivity over hERG
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Cathepsin K | polymer | 215 | 23523.5 | 1 | UniProt (P43235) Pfam (PF00112) | Homo sapiens (human) | Cathepsin O, Cathepsin X, Cathepsin O2 |
| 2 | B (A) | 3-{2-[(E)-iminomethyl]-6-propylpyrimidin-4-yl}-N,N-dimethyl-5-(trifluoromethyl)benzamide | non-polymer | 364.4 | 1 | Chemie (O47) | |||
| 3 | C (A) | water | water | 18.0 | 151 | Chemie (HOH) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 23523.5 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 364.4 | |
| All* | Total formula weight | 23887.8 |
