3NZC
Structural Analysis of Pneumocystis carinii and Human DHFR Complexes with NADPH and a Series of Five Potent 5-(omega-carboxy(alkyloxy)pyrido[2,3-d]pyridine Derivativea
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (X) | Dihydrofolate reductase | polymer | 206 | 23918.5 | 1 | UniProt (P16184) Pfam (PF00186) | Pneumocystis carinii | |
| 2 | B (X) | 6-[2-methoxy-5-(2-phenylethoxy)benzyl]-5-methylpyrido[2,3-d]pyrimidine-2,4-diamine | non-polymer | 415.5 | 1 | Chemie (D2O) | |||
| 3 | C (X) | PHOSPHATE ION | non-polymer | 95.0 | 1 | Chemie (PO4) | |||
| 4 | D, E (X) | GLYCEROL | non-polymer | 92.1 | 2 | Chemie (GOL) | |||
| 5 | F (X) | water | water | 18.0 | 48 | Chemie (HOH) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 23918.5 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 694.6 | |
| All* | Total formula weight | 24613.2 |
