3NW5
Crystal structure of insulin-like growth factor 1 receptor (IGF-1R-WT) complex with a carbon-linked proline isostere inhibitor (11B)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Insulin-like growth factor 1 receptor | polymer | 307 | 35041.2 | 1 | UniProt (P08069) Pfam (PF07714) In PDB | Homo sapiens (human) | Insulin-like growth factor I receptor, IGF-I receptor |
| 2 | A | N-(5-cyclopropyl-1H-pyrazol-3-yl)-2-{(2R)-1-[(6-fluoropyridin-3-yl)carbonyl]pyrrolidin-2-yl}pyrrolo[2,1-f][1,2,4]triazin-4-amine | non-polymer | 432.5 | 1 | Chemie (LGX) | |||
| 3 | water | water | 18.0 | 205 | Chemie (HOH) |
Sequence modifications
A: 952 - 1256 (UniProt: P08069)
| PDB | External Database | Details |
|---|---|---|
| Met 950 | - | expression tag |
| Val 951 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 35041.2 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 432.5 | |
| All* | Total formula weight | 35473.7 |
