3NUM

Substrate induced remodeling of the active site regulates HtrA1 activity

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Serine protease HTRA1	polymer	332	36425.6	1	UniProt (Q92743) Pfam (PF13365) Pfam (PF17820) In PDB	Homo sapiens (human)	L56, Serine protease 11

Sequence modifications

A: 158 - 480 (UniProt: Q92743)

PDB	External Database	Details
Met 157	-	initiating methionine
Ala 328	Ser 328	engineered mutation
Leu 481	-	expression tag
Glu 482	-	expression tag
His 483	-	expression tag
His 484	-	expression tag
His 485	-	expression tag
His 486	-	expression tag
His 487	-	expression tag
His 488	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	36425.6
All*	Total formula weight	36425.6

*Water molecules are not included.