3NUJ
Crystal Structure of HIV-1 Protease Mutant I54V with Antiviral Drug Amprenavir
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | Protease | polymer | 99 | 10726.6 | 2 | UniProt (P03366) Pfam (PF00077) In PDB | Human immunodeficiency virus 1 | |
2 | A, B | IODIDE ION | non-polymer | 126.9 | 19 | Chemie (IOD) | |||
3 | B | {3-[(4-AMINO-BENZENESULFONYL)-ISOBUTYL-AMINO]-1-BENZYL-2-HYDROXY-PROPYL}-CARBAMIC ACID TETRAHYDRO-FURAN-3-YL ESTER | non-polymer | 505.6 | 1 | Chemie (478) | |||
4 | water | water | 18.0 | 132 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 99 (UniProt: P03366)
PDB | External Database | Details |
---|---|---|
Lys 7 | Gln 507 | engineered mutation |
Ile 33 | Leu 533 | engineered mutation |
Val 54 | Ile 554 | engineered mutation |
Ile 63 | Leu 563 | engineered mutation |
Ala 67 | Cys 567 | engineered mutation |
Ala 95 | Cys 595 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 21453.3 | |
Non-Polymers* | Number of molecules | 20 |
Total formula weight | 2916.8 | |
All* | Total formula weight | 24370.1 |