3NU6
Crystal Structure of HIV-1 Protease Mutant I54M with Antiviral Drug Amprenavir
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Protease | polymer | 99 | 10758.7 | 2 | UniProt (P03366) | Human immunodeficiency virus 1 | |
| 2 | C, G, H (A, B) | CHLORIDE ION | non-polymer | 35.5 | 3 | Chemie (CL) PubChem (312) | |||
| 3 | D (A) | SODIUM ION | non-polymer | 23.0 | 1 | Chemie (NA) PubChem (923) | |||
| 4 | E, I (A, B) | ACETATE ION | non-polymer | 59.0 | 2 | Chemie (ACT) PubChem (175) | |||
| 5 | F (B) | {3-[(4-AMINO-BENZENESULFONYL)-ISOBUTYL-AMINO]-1-BENZYL-2-HYDROXY-PROPYL}-CARBAMIC ACID TETRAHYDRO-FURAN-3-YL ESTER | non-polymer | 505.6 | 1 | Chemie (478) PubChem (22868212) PubChem (44342222) PubChem (68164690) PubChem (441385) PubChem (59964701) PubChem (124638074) PubChem (10885665) PubChem (11168069) PubChem (68088939) PubChem (68336859) PubChem (2177) PubChem (65016) PubChem (92209736) PubChem (6540587) PubChem (9898472) PubChem (141823677) | |||
| 6 | J, K (A, B) | water | water | 18.0 | 232 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 99 (UniProt: P03366)
| PDB | External Database | Details |
|---|---|---|
| Lys 7 | Gln 507 | engineered mutation |
| Ile 33 | Leu 533 | engineered mutation |
| Met 54 | Ile 554 | engineered mutation |
| Ile 63 | Leu 563 | engineered mutation |
| Ala 67 | Cys 567 | engineered mutation |
| Ala 95 | Cys 595 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 21517.4 | |
| Non-Polymers* | Number of molecules | 7 |
| Total formula weight | 753.1 | |
| All* | Total formula weight | 22270.5 |
